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Obvious immune paralysis occurs in the later stage of sepsis, which often indicates poor prognosis and high mortality (274)

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Behavioral measurements should primarily include the percentage of time spent in the open quadrant, the percentage of entries into the open quadrant, the number of times the animal peeks down from the edge of the platform while in the open or closed quadrant, and the number of stretch-attend postures from the closed quadrant to the open quadrant

BPC-157 also modulates nitric oxide (NO) synthesis pathways, contributing to both mucosal protection and systemic vascular effects